The treatment of rheumatoid arthritis (RA) is directed toward the control of synovitis and the prevention of joint injury. Support for an early aggressive appro INTRODUCTION. Leflunomide (LEF) is an isoxazole derivative used for the treatment of rheumatoid arthritis (RA). LEF, which inhibits pyrimidine synthesis, is structurally unrelated to other immunomodulatory disease-modifying antirheumatic drugs (DMARDs), exhibiting a distinct mechanism of action compared with other DMARDs used to treat RA. RA Medications: What is the Best Medication for Rheumatoid Arthritis? Advancements in medical technology now make it possible for many rheumatoid arthritis (RA) patients to receive medical treatments which allow them to continue living a high quality of life. While there is as yet no cure for Rheumatoid Arthritis, the progression and the symptoms of this chronic condition can be managed. Goals of the treatment include alleviating pain, slowing and stopping joint damage, reducing swelling, and helping individuals become more active and attain healthier lifestyles. RA Research Briefs: Lung Disease, Remission, Children of RA Patients. Keep up-to-date on the latest rheumatoid arthritis (RA) research with our brief research summaries. Nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying antirheumatic drugs (DMARDs), and biologics treat rheumatoid arthritis (RA). Learn more about the different classes of RA medications and their side effects. User Reviews for Arava to treat Rheumatoid Arthritis. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Rheumatoid arthritis is best diagnosed by a rheumatologist, a type of doctor that is a specialist in arthritis and autoimmune diseases. To diagnose RA, a doctor will take a complete history and perform a thorough physical examination. Find patient medical information for Leflunomide Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. If you’re diagnosed with rheumatoid arthritis (RA), your doctor and rheumatologist will work with you to reduce painful symptoms and slow the progression of the disease.